Beilstein J. Org. Chem.2016,12, 2420–2442, doi:10.3762/bjoc.12.236
economy; green organic synthesis; integerpartitioning; reactions; probability; retrosynthetic analysis; ring construction strategy; Introduction
The ring motif is a key feature in chemical structures that has long attracted the attention of synthetic organic chemists in their quest to implement novel
of ring construction strategy from a very different perspective that is rooted in an entirely different scientific field which also has enjoyed an even longer track record of research, namely combinatorics and enumeration. Specifically, we exploit the subject of integerpartitioning [123][124][125
for a given molecular formula of a hydrocarbon [127][128], and parameterizing chemical properties with topological indices [129][130][131]. However, none of these integer applications involves partitioning of those integers. In this work we apply the concept of integerpartitioning to retrosynthetic
PDF
Graphical Abstract
Figure 1:
Possible two-component couplings for various monocyclic rings frequently encountered in organic mol...